Researchers using CRISPR eliminate HIV infection in mice
Using gene-editing technology, researchers from the University of Pittsburgh and the Lewis Katz School of Medicine at Temple University (LKSOM) have managed to eliminate HIV infections in mice carrying human cells. CRISPR/Cas9 was the method employed by the same researchers in 2016 to analyze the genome of mice infected with HIV-1. CRISPR/Cas9 genetic engineering may help overcome this by recombining the genes of pig embryos to get rid of the virus' DNA. Although researchers claim to be "cautiously optimistic," this has become the first study to effectively shut down the HIV replication process. Later, they focused on mice with an acute infection, in which the HIV actively replicates.
A new gene-editing technique has eliminated acute HIV infection in living animals
The technique has been demonstrated in animals with both acute and latent HIV, and was successful in human immune cells transplanted into mice. That's why patients have to remain on medication for their entire lives - latent HIV can activate within weeks if treatment stops. In a third animal model, the researchers transplanted human immune cells into mice before infecting them with a latent HIV-1 virus. "We also show that the strategy is effective in two additional mouse models, one representing acute infection in mouse cells and the other representing chronic, or latent, infection in human cells." For the first time, researchers have used gene-editing to eliminate HIV DNA from the genomes of three different animal models to ensure that replication of the virus was completely shut down.collected by :Lucy William
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