Inovio Pharmaceutical's DNA vaccine will be tested in patients with HIV quoting : Philly

Once in the body - through an inoculation in the arm - the DNA gets into critical immune cells that attack HIV. Inovio's immunotherapy, Pennvax GP, will be tested in HIV-positive patients to see if it generates killer T cells in the body's immune system to attack the HIV virus. In theory if we are lucky, it will allow us to one day stop antiretroviral drugs and let the immune system to take over." Inovio Pharmaceuticals in Plymouth Meeting is collaborating with the University of California San Francisco, which received a $6.95 million grant from the National Institutes of Health, to test the biotech company's DNA-based vaccine to reduce or prevent the HIV virus. Inovio's vaccine will be tested alone and in combination with other products in patient trials at the University of California in San Francisco and Los Angeles.




Scientists say they've engineered an 'on-off switch' into a weakened form of HIV, enhancing the safety and effectiveness of a potential vaccine for the virus. NEW COMBINATION OF DRUGS COULD ELIMINATE HIV HIV could be eliminated using a novel combination of drugs, claims a research team on the brink of an unprecedented experiment. Each codon instructs an amino acid to connect to a chain that becomes a protein and ultimately allows viral replication. Doing so required the team to replace a codon that codes for the amino acid in the HIV's genetic code. When the team supplied the synthetic amino acid, the assembly line began churning out proteins, and the virus began replicating.

Researchers one step closer to HIV vaccine

Researchers at the University of Nebraska are one step closer to creating an effective vaccine to guard against HIV. The team genetically engineered an on-off switch in a weakened form of the virus, making a potential vaccination that much safer and more effective, according to a study published Wednesday in the journal ACS Synthetic Biology.


collected by :Lucy William
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