To test Zika vaccines, scientists need a new outbreak
If successful, the product could protect humans against a number of mosquito-transmitted diseases, including Zika virus, dengue and chikungunya. Warmer-than-usual temperatures are affecting areas across the Western Hemisphere, including hotbeds of the Zika outbreak in Brazil. Researchers are eager to test promising vaccines against Zika, the virus that sparked a global health emergency last year. But uncertainty over whether the Zika epidemic will continue affects researchers' ability to finish testing vaccines. The uncertainty poses challenges for Zika vaccine development.The new mouse model could be used in further research to investigate the immune response to Zika virus. A digitally-colorized transmission electron micrograph (TEM) of Zika virus, which is a member of the family Flaviviridae. "Our findings are particularly exciting because we now know that we can study the immune response to Zika virus in mice with a normal immune system," the authors explain. Like other viruses, Zika virus caused an innate and adaptive immune response in the mice. This approach led to identification of a specific portion ("epitope") of a Zika virus protein that is recognized by mouse T cells.
collected by :Lucy William
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