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Researchers identify mechanism in chikungunya virus that controls infection, severity -- ScienceDaily
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Researchers led by the Johns Hopkins Bloomberg School of Public Health have identified a mechanism by which the chikungunya virus infects healthy cells and controls how severe the disease it causes will be, a mechanism they believe can be found in a number of other related viruses for which there are no treatments or licensed vaccines.The findings, published Jan. 30 in the Proceedings of the National Academy of Sciences, could be a first step toward developing drugs to treat or prevent diseases caused by alphaviruses (such as chikungunya) and coronaviruses (such as SARS)."We feel we have now identified a fundamental mechanism which the chikungunya virus uses during infection that determines how dangerous the chikungunya infection will be," says study leader Anthony K. L. Leung, PhD, an assistant professor in the Department of Biochemistry and Molecular Biology at the Bloomberg School.
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Repurposing 2 autoimmune drugs for chikungunya virus
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Two new studies explore strategies that could offer relief from the debilitating joint pain caused by Chikungunya virus infections, an emerging disease with no known therapies.Chikungunya virus is a mosquito-borne illness that has rapidly spread throughout the Americas, with more than 1.7 million suspected cases since the first incidence of local transmission was detected in the Caribbean in 2013.The treatment regimens employed drugs that have already been approved for human use in other applications, and each reduced joint swelling in mice infected with the virus - potentially paving the way to much needed therapeutic options.
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Johns Hopkins researchers uncover mechanism in chikungunya virus that controls disease severity
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Researchers led by the Johns Hopkins Bloomberg School of Public Health have identified a mechanism by which the chikungunya virus infects healthy cells and controls how severe the disease it causes will be, a mechanism they believe can be found in a number of other related viruses for which there are no treatments or licensed vaccines.The findings, published Jan. 30 in the Proceedings of the National Academy of Sciences, could be a first step toward developing drugs to treat or prevent diseases caused by alphaviruses (such as chikungunya) and coronaviruses (such as SARS)."We feel we have now identified a fundamental mechanism which the chikungunya virus uses during infection that determines how dangerous the chikungunya infection will be," says study leader Anthony K. L. Leung, PhD, an assistant professor in the Department of Biochemistry and Molecular Biology at the Bloomberg School.
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