Enormous promise for new parasitic infection treatment stat : EurekAlert

Whipworm eggs are passed from infected faeces into people by hand to mouth contact. However the new compounds are effective against the eggs and could be developed into a spray which can stop infection at source. Whipworm eggs are also affected by the compounds. ###The paper, Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo', was published in PLOS Neglected Tropical Diseases. The researchers found that the compounds kill the adult stages of the whipworm much more effectively than existing drugs.




Whipworm eggs are passed from infected faeces into people by hand to mouth contact. Current treatments for human whipworm are based on 1960s drugs initially developed for livestock and have a low success rate in people. Explore further: Parasitic worms of pigs could provide new treatments of human diseasesMore information: Frederick A. Partridge et al. However the new compounds are effective against the eggs and could be developed into a spray which can stop infection at source. The team from the three UK universities, whose results have been published in the journal PLOS Neglected Tropical Diseases, studied a class of dihydrobenzoxazepinones, not previously associated with controlling whipworms.


LONDON, Feb. 22 (Xinhua) -- Scientists in Britain said Wednesday they have developed a new drug in the fight against a parasite infection affecting 500 million people worldwide. The research team say current treatments for human whipworm are based on 1960s drugs initially developed for livestock, but they have a low success rate in people. The team from the three British universities, whose results have been published in the journal PLOS Neglected Tropical Diseases, studied a class of dihydrobenzoxazepinones, not previously associated with controlling whipworms. "The researchers found that the compounds kill the adult stages of the whipworm much more effectively than existing drugs," a spokesman at the University of Manchester said. Research has shown the human whipworm, which can damage physical and mental growth, is killed at egg and adult stage by a new drug class developed at the Universities of Manchester and Oxford and at University College London.



collected by :Lucy William
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