Zika eliminates features human tumour in central nervous system of rodents

According to Okamoto, these tumour cells by stem cell-such as characteristics have been observed in several kinds of solid tumour including those which affect the central nervous system. Extremely we had the idea of investigating whether the virus too attacked tumour stem cells in the central nervous system," he said. The experiments were performed by 3 human tumour cell lines: 2 derived from medulloblastoma & the 3rd from atypical teratoid/rhabdoid tumour (AT/RT). "The neural stem cells which undergo these alterations give height to tumour cells at a later phase. The 2nd experiment consisted of comparing Zika virus's capacity to infect healthful neural stem cells obtained from induced pluripotent stem cells (adult cells reprogrammed in the lab to behave such as stem cells) by its contagion of CNS tumour stem cells.

Marmoset monkey model of Zika contagion offers Fresh insights into the human condition

Kjersti Aagaard, M.D., Ph.D.A novel marmoset model of human Zika contagion offers Fresh opportunities for better understanding of the method the virus causes congenital illness in humans. The investigators found which contagion of marmoset dams recapitulates the human contagion further faithfully than contagions in other animal models, providing opportunities to research illness repercussions in ways which weren't formerlyobtainable. For instance, other human viral contagions, like those caused with lassa fever virus, Ebola virus/Marbug virus & dengue fever & West Nile virus, could be reproduced in the popular marmoset. too, the investigators had shown before which Zika contagion in male popular marmosets resembles many aspects of the contagion seen in humans. "We had formerlydemonstrated which Zika replicates in placental cells isolated from normal human term pregnancies, enabling the placenta to serve as a reservoir for the virus & an eventual portal to the emerging fetus.

In Analysis by mice, Zika eliminates human brain tumour popular in Kids

according to The article is called "Zika selectively kills aggressive human embryonal CNS tumour cells in vitro & in vivo" & was published on-line this Thursday. "CNS tumors are the generality popular solid tumors in Kids & Teenagers," explains Keith Okamoto, 1 of the research's lead authors. Concentrations of 2 viral particles per cell killed generality of the CNS tumour cells, however had tiny influence on the other lineages. & even reduce amounts of virus, of 1 viral particle per 10 cells, inhibited the development of CNS tumour cells. In the in vivo experiments, embryonic CNS tumors, that are of human origin, were grafted onto mice.

collected by :Lucy William