Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen : Nature Medicine : Nature Research : nature

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Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen : Nature Medicine : Nature Research

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen : Nature Medicine : Nature Research

Human forebrain-specific NPCs, astrocytes, organoids and cell line cultures.The human iPSC line (C1-2 line) was previously generated from a skin biopsy sample of a healthy male newborn and has been fully characterized and passaged on mouse embryo fibroblast (MEF) feeder layers60.The BJ line was derived from healthy control fibroblasts obtained from the American Type Culture Collection (ATCC) (CRL-2522, male, neonatal).


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Tapeworm drug could cure Zika virus infection

Tapeworm drug could cure Zika virus infection

Tapeworm drug could cure Zika virus infectionResearchers have found some existing drug compounds -- including one already used as a treatment for tapeworm infection in humans -- that have the potential to both stop Zika from replicating in the body and from damaging the crucial fetal brain cells that lead to birth defects in newborns."This is a first step toward a therapeutic that can stop transmission of this disease," said one of the researchers Hengli Tang, Professor at Florida State University in the US.In a paper published in the journal Nature Medicine, the investigators said they screened 6,000 existing compounds currently in late-stage clinical trials or already approved for human use for other conditions, and identified several compounds that showed the ability to hinder or halt the progress of the Zika virus in lab-grown human neural cells.


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First case of locally-transmitted Zika virus infection reported in Singapore: MOH, NEA

First case of locally-transmitted Zika virus infection reported in Singapore: MOH, NEA

SINGAPORE: A 47-year-old Malaysian woman living at Block 102 Aljunied Crescent is Singapore's first reported case of locally-transmitted Zika virus infection, the Ministry of Health (MOH) and National Environment Agency (NEA) said on Saturday (Aug 27).As she had not travelled to Zika-affected areas recently, she was likely to have been infected in Singapore, MOH and NEA said in a joint news release.According to MOH and NEA, the patient had developed symptoms such as fever, rash and conjunctivitis from Thursday.

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen : Nature Medicine : Nature Research